Quattro Pulse Stimulation

This innovative, new patterned repetitive transcranial magnetic stimulation protocol called quadri-pulse stimulation (QPS) can generate a broad range of motor cortical plasticity ranging from MEP suppression to MEP facilitation. In addition to evoking lasting cortical plasticity changes, QPS can also be used to evaluate priming effects: when used as a priming stimulation, which does not induce an LTP- or LTD-like phenomena itself, it can nevertheless change the threshold for LTP- or LTD-like plasticity caused by consecutive stimulations. Said effects enable the examination of metaplasticity theories in more details in humans. Other more clinical applications of QPS are being researched towards inducing symptomatic relief in patients with neurological or psychiatric disorders, such as Parkinson‘s disease, depression, or intractable pain.

Our new technology platform enables for the first the combination of ultra-fast QPS and online TMS-EEG in one sinlge device.

Major considerations and solutions:

Safe operation of the stimulator
Safety channel to immediately stop of the stimulation if necessary.
Patented safety concept for setting safety borders of stimulation intensity and frequency.

Combination of QPS stimulation with EEG
Biphasic QPS pulses for minimization of stimulation artifact.
Advanced shielding of stimulator and to avoid interferences by mains noise.

Comparison of various stimulation protocols
All-in-one stimulation equipment enables QPS, TBS and rTMS in one device.

Integration into existing research labs
Various possibilities to control the stimulation with existing equipment.

Why MAG & More:
Safety borders
Optimized coil design
Precise timing
No mains noise
High frequenzy TMS
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